Revitalize Your Health and Fitness

Metabolism slows down with age, causing weight gain. NAD+ aids the body in generating adenosine triphosphate (ATP), which converts food into fuel to keep us active throughout the day. 

NAD+ peptide:

• Improves your metabolism and energy levels.

• May enhance brain function, memory, and concentration.

• May repair DNA and enhance life span.

• Promotes faster healing and recovery.

Nicotinamide mononucleotide (NMN) is a molecule that is produced naturally in the human body. NMN plays a key role in cellular energy production and DNA repair. NMN is derived from ribose, nicotinamide, nicotinamide riboside and niacin. In addition, a number of our bodies' enzymes use NMN to generate nicotinamide adenine dinucleotide (NAD). NMN is a key molecule for biohacking, as it contributes to improving the body’s health and wellness at the cellular level.

Nicotinamide mononucleotide (NMN) has several health benefits, including: 

• Increasing insulin sensitivity
• Reversing mitochondrial dysfunction
• Extending lifespan
• Increasing NAD+ biosynthesis
• Preventing age-associated weight gain
• Improving cardiovascular health and blood flow
• Enhancing energy metabolism
• Promoting brain and muscle function
• Protecting against obesity and diabetes
• Potentially slowing down and reversing the aging process.

Nicotinamide riboside (NR) is a vitamin B3 analog that has gained significant attention in the scientific community for its role in promoting cellular health and possibly slowing down the aging process. 

• Enhances cellular health (NR is a precursor to NAD+, which plays a crucial role in cellular metabolism and energy production)

• Promotes longevity

• NR reduces markers of aging, rejuvenates organ function, and extends lifespan.

• Improves brain health 

• NR helps repair DNA and prevents neurodegenerative diseases.

• Enhances metabolic rate.

• Boosts heart health.

• Supports exercise performance and recovery.

• Promotes weight management.

Epithalon is a synthetic tetrapeptide isolate composed of the four amino acids alanine, glutamic acid, aspartic acid, and glycine. It is derived from epithalamin, a crude polypeptide extracted from the pineal gland. Epithalon is used to regulate the cell cycle through upregulation of telomerase activity. It has been shown to have distinctive anti-aging and anti-tumor activity across many animal and human studies.

Epithalon activates the telomerase enzyme, aiding cells in lengthening their telomeres (the protective part of DNA). As a result, cell life span increases, and aging is slowed down. 

Epithalon also:

• Improves skin texture.
• May heal damaged muscle cells.
• Prevents age-related disorders like dementia and heart issues.

FOXO4-DRI has the potential to slow down cellular aging — a phase where cells lose their capacity to divide and work. 

Also, it:

• Promotes cell survival and growth.

• May improve sperm quality and enhance the testosterone level in aged men.

• Boosts the production of collagen and elastin.

• Aids in the destruction of aging cells.

• Enhances cell regeneration.

L-glutathione is an antioxidant peptide that mainly helps to reduce oxidative stress, a major factor behind aging. 

It was observed that L-glutathione has the capacity to reduce wrinkles and fine lines. Also, it:

• Evens out the skin tone and gives a brightening effect.
• Replaces damaged cells with new ones.
• Removes impurities and toxins from the body.

SYN-AKE mimics the action of a peptide found in snake venom. It prevents certain neurotransmitters from binding to muscle receptors, which relaxes facial muscles. 

SYN-AKE could:

Decrease fine lines.

Minimize wrinkles around the upper lip and mouth.

Due to its high anti-aging efficacy and safety profile, SYN-AKE may show promising results in anti-aging formulations.

GHK-Cu (copper tripeptide-1) is one of the best peptides for women due to its therapeutic potential for hair growth and skin elasticity. GHK-Cu promotes the synthesis of elastin, which facilitates blood flow to the skin. 

GHK-Cu Benefits:

• Tightens loose skin and enhances elasticity.
• Decreases photodamage of skin.
• Expands cell population to repair skin cells.
• GHK-Cu is also one of the best peptides for tendon repair. 

Nicotinamide adenine dinucleotide (NAD+) is a key coenzyme found in all living cells. It is a dinucleotide, which means that it consists of two nucleotides joined through their phosphate groups. One nucleotide contains an adenine base, and the other contains nicotinamide.

NAD+ is essential for life, one of the most versatile molecules in the body, and an important area of focus for aging research. Before we dive into the various things NAD+ does in the body, let’s take a quick look at its history.

NAD+ is important for the mitochondria, the powerhouses of our cells, to produce the energy our cells need. It functions as a coenzyme in the mitochondria, allowing the creation of chemical energy that our bodies can then use.

Metabolic processes such as glycolysis, the citric acid cycle (TCA/Krebs cycle), and the electron transport chain inside the mitochondria all rely on NAD+ in order to function.

In its function as a ligand, NAD+ binds to enzymes and transfers electrons between molecules.This means that NAD+ is found in two forms in the cell; NAD+ is an oxidizing agent that takes electrons from other molecules in order to become its reduced form, NADH. NADH can then become a reducing agent that donates the electrons it carries.

As electrons are the atomic basis of cellular energy, transferring them between molecules means that NAD+ works almost like recharging a battery. A battery goes flat because its electrons are used up to provide energy. The electrons cannot return to their charged state without a jolt, and it is the same in our cells. NAD+ gives the molecules the jolt they need to become active again, and in this way, NAD+ is able to increase or decrease enzyme activity, gene expression, and cell signaling.

Due to its critical importance in the body, most organisms can produce NAD+ in a few alternative ways. Humans like us have three major pathways to create NAD+: the de novo pathway, the Preiss–Handler pathway, and the salvage pathway.

In biochemistry, de novo means that a molecule is created directly from another molecule: in the case of NAD+, the niacin molecule is built from scratch using the essential amino acid L-tryptophan (TRP). The de novo is the only non-vitamin B3 pathway for the creation of NAD+.

The Preiss–Handler pathway is one of the vitamin B3 pathways and starts with either nicotinic acid (NA) or niacinamide (NAR). The NA or NAR present in the food we consume is then converted via a series of enzymatic reactions into NAD+. As the above diagram shows, this pathway and the de novo pathway both join at the point where they become NaNM and continue along the same path to become NAD+. Niacin is perhaps the best-known name for nicotinic acid, and as a 2020 human trial showed, niacin increases NAD+ significantly in muscle tissue.

Finally, the salvage pathway converts nicotinamide (NAM), also known as niacinamide, into NAD+. This pathway has nicotinamide mononucleotide (NMN) as an intermediate, and nicotinamide riboside (NR) also uses the same salvage pathway. This pathway is called the salvage pathway because instead of using the usual precursor molecules, such as TRP or Vitamin B3, to make NAD+, this pathway recycles (salvages) NAM, which is often generated from NAD+, back into NAD+ again.

Of the NAD+ pathways, perhaps the most recent focus has been on the salvage pathway and the NAD+ precursor molecules NMN and NR. 

• Boosting energy: Increases energy levels and reduces fatigue.

• Enhancing cognition: Improves focus, memory, and mental clarity.

• Supporting cellular health: Promotes DNA repair and overall cell function.

• Addressing aging: Replenishes declining NAD+ levels, potentially delaying aging.

• Strengthening immunity: Enhances immune system function and resilience.

• Aiding addiction recovery: Alleviates withdrawal symptoms and restores brain function.

The above statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

There are several ways to increase NAD+ levels in the body:

Dietary intake

Consuming foods rich in vitamin B3, such as fish, poultry, whole grains, mushrooms, and peanuts, can help increase NAD+ levels.

Supplements

Various supplements can boost NAD+ levels, including nicotinamide riboside (NR) and nicotinamide mononucleotide (NMN), which are both precursors to NAD+.

Exercise

Regular physical activity has been shown to increase NAD+ levels by stimulating cellular energy production and promoting mitochondrial biogenesis.

Caloric restriction

Reducing calorie intake without malnutrition can elevate NAD+ levels and activate sirtuins, leading to enhanced longevity and health span.

Intermittent fasting

Periodic fasting can increase NAD+ levels and stimulate autophagy, a cellular recycling process that promotes optimal cellular function.

Depending on your goals, you might get a:

Microdose (200 mg): Used by healthy folks to get an energy boost.

Low dose (400 mg): The starting dose for anti-aging and reducing fatigue.

Moderate dose (800 mg): Improved cognitive function.

High dose (1000 mg or more): Better neurotransmitter function, fewer withdrawal symptoms.

These rough figures are a starting point: your dose might take trial and error to pinpoint. But the effort is worth the benefits you experience once you nail it down.