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Selective Androgen Receptor Modulators (SARMs) have emerged as a popular alternative to traditional steroids and prohormones. They offer a way to achieve muscle growth, fat burning, and full-body recomposition with potentially fewer side effects.
SARMs, which is short for Selective Androgen Receptor Modulators, are a group of drugs commonly lumped together because of their similar mechanism of action.
From their name alone, one can deduce that they selectively bind and modulate the androgen receptor, without affecting other areas of the body.
SARMs were first discovered in the 1940s and from there on further developed until the 1990s, when the first SARMs we know of today became freely available to the public.
Unlike steroids or prohormones, SARMs don’t aromatize into estrogen nor do they affect the prostate, meaning that they are tissue-selective in their mechanism of action.
The biggest advantage of SARMs is their high affinity to the androgen receptor, which means that they work well in low dosages and promote benefits such as muscle building, increasing strength, endurance and so on.
SARMs target selective tissues. Muscle and bone are the main targets of SARMs, where stimulation of anabolic effects includes these primary benefits:
Androgens are steroid hormones that bind to androgen receptors in cells around the body. Androgens can occur naturally in the body or be created synthetically in a lab. The most well-known androgen is the primary male sex hormone, testosterone.
The primary role of androgen is to:
Direct, regulate and maintain male characteristic development through the process of androgen receptor binding.
In performance enhancement, androgens taken at higher doses promote the increased ability to build muscle, develop more strength, and perform physically at a higher level.
Androgens like testosterone are called anabolic steroids. Other steroids are usually modified versions of testosterone, as well as DHT. While anabolic steroids are potent androgens with a strong anabolic nature, their androgenic activity is generally very strong, resulting in a host of unwanted side effects.
A selective receptor modulator (or just SRM) is a drug or compound that can cause different effects in different tissue types in the body. An SRM can either stimulate or block a specific receptor. Where a receptor can be stimulated, it’s possible to bring about the beneficial effects for which the receptor is responsible.
Specifically, regarding SARMs, we would be most interested in the selective receptors in the muscle that stimulate muscle growth. Because they are selective, side effects are minimized because non-targeted receptors are not (in theory) going to be activated.
SARMs are far from perfect, and most will result in some activation of androgen receptors outside those desired targeted ones.
SARMs, with their selectivity, will rarely be as androgenic as steroid androgens like testosterone.
Ostarine is purported to be one of the safest and mildest SARMs in existence. The reason why it’s believed to be so safe is because of the many human studies performed on it, making it the most popular and widely used SARM as of now.
Ostarine is most commonly used for cutting cycles and one has to be careful with dosages, as it can cause suppression to occur, despite being described as relatively mild.
Ostarine Benefits
Ostarine Side Effects
Testosterone Suppression
Even though Ostarine is a mild SARM, use in normal dosages should not exceed eight weeks. It can cause mild suppression to occur by week seven. It will go away on its own after a month and you won’t need PCT for it.
The most common side effects which follow suppression are lethargy and low libido levels.
Headaches
They usually occur in the first week of usage and completely disappear afterwards, not much you can do about them.
Disturbed Sleep Pattern
A small minority of people report sleep disturbances from Ostarine usage. It’s very rare for this side effect to occur, but it is still good to know that it can happen to you.
Hair Loss
Only experienced by a handful of people on astronomical dosages (about 50mgs a day or more). If you stick to normal dosages, you will not have a problem with hair loss from Ostarine.
Ostarine Results
In one eight-week cutting cycle, researchers can expect to lose between five to ten pounds of weight, as well as 3 to 5% of total body fat. Some lean muscle mass may also be gained.
Ostarine will protect your muscle mass from deteriorating during a cutting cycle so strength loss will not occur.
If bulking, Ostarine may result in gains of five to seven pounds of lean muscle mass, while also contributing to a loss of body fat.
Andarine is very similar to Ostarine as it has been developed by the same company.
Andarine has very high bioavailability and is better at building muscle tissue and promoting bone health when compared to Ostarine, but this has only been tested on animals so far.
Andarine Benefits
Andarine Side Effects
Yellow Tint In Vision
This side effect is most pronounced at nighttime, where users have reported difficulties adjusting their vision to light while on Andarine.
Also, there is a visible yellow tint experienced by those who take Andarine in higher dosages, which does go away once the drug is discontinued, but still causes a lot of discontent for the afflicted user.
You don’t have to be afraid of Andarine, just don’t consume it in astronomical dosages and you should have no issues with your vision.
Mild Suppression
According to researchers, Andarine is the least suppressive SARM of them all, and that you don’t have to worry that much about suppression.
No PCT is required for Andarine.
Andarine Results
Andarine is typically used during a cutting cycle and results in muscles looking defined, even at low body fat percentages. Overall body composition will also see noticeable improvement.
At the completion of an eight-week cycle, gains of 2 to 5 pounds of muscle mass and a loss of 3 to 5% of total body fat are typical.
Researchers should maintain their diet and exercise routines to optimize an Andarine cycle.
LGD-4033, also known as Ligandrol or VK5211 is a non-steroidal SARM that is known to be a full agonist of the androgen receptor.
It has very high affinity and bioavailability, making it a very good compound to take orally.
Allegedly, LGD-4033 is the strongest SARM out there when measured on a mg-to-mg basis.
Ligandrol has enjoyed multiple human studies, and they all confirmed this SARM to be safe and well-tolerated for human consumption, even in dosages as high as 22mgs.
Ligandrol Benefits
Ligandrol Side Effects
Testosterone Suppression
Ligandrol is the most suppressive SARM currently available on the market. Don’t take more than 2.5-5mgs a day for eight weeks, unless you want to be completely suppressed and in need of PCT.
Stick to recommended dosages and cycle lengths.
Water Retention
Water retention is a real problem with Ligandrol, more so than in other SARMs. You need to drastically increase your water intake while on LGD-4033, as to avoid this problem from occurring in your body.
Even if it does happen to you, it will quickly go away once your cycle ends, so there is nothing to worry about.
Testicle Pain
Researchers have claimed to experience testicle pain while on their Ligandrol cycle. The pain is described as short and sharp, but it is relatively rare and if you do experience it, you’ll have to simply tough it out – the gains are definitely worth it in this scenario.
No permanent damage has been reported.
Insomnia
This is the rarest side effect out of them all and affects only around 1% of those who take Ligandrol.
Ligandrol Results
You will be able to bulk the entire time with minimal fat gain and the results will be quite noticeable. Strength and energy will increase greatly.
RAD-140 has some very similar effects on the body as testosterone does, and this SARM is highly regarded for its ability to produce significant gains in both strength and lean muscle. This makes it one of the most popular bulking SARMs available.
RAD-140 is such a powerful SARM that new users are strongly recommended to use it only at very low doses.
Studies have shown that RAD-140 increases lean muscle mass exceptionally well by targeting skeletal tissue androgen receptors.
RAD-140 is believed to be the most androgenic SARM, but despite this, its androgenic activity is only around 10% of that of testosterone.
BENEFITS:
RAD-140 is a powerful bulking SARM that makes it easier and faster for you to gain muscle. It boosts your strength beyond normal levels, substantially increases stamina, and speeds up your recovery:
RAD-140 is great for a bulking cycle. It can also help you burn fat, thanks to its promotion of increased anabolic activity.
RISKS:
RAD-140 can cause some of the androgenic side effects that you might be familiar with from steroids. These RAD-140 side effects are less likely at lower doses, though. These include hair loss, extra aggression or anxiety, acne, and even increased blood pressure. Some users report loss of appetite, dizziness, lethargy, and insomnia as other side effects. This SARM will also cause testosterone suppression.
RAD-140 is one of the most powerful SARMs developed to date. With this comes some of the more serious side effects we will see with any SARM, but not everyone will have the same experience!
Researchers need to see how they react to Testolone and adjust the dosage and cycles to get the best results. RAD-140 has great potential to be an even better choice than steroids for a serious bulking cycle.
DOSAGE:
RAD-140 will often be used at 10-20 mg/day for 6-8 weeks.
The compound has a 24-hour half-life (up to 60 hours according to some users), so the dosing frequency is once a day (preferably in the morning) to ensure it’s always active in the body.
RAD-140 is so powerful, researchers should start at a low dosage of 5mg and increase the dose gradually throughout your cycle. A 6-week cycle provides a good balance between benefits and side effects.
Some researchers claim S-23 is the strongest SARM there is, comparing it to the steroid Winstrol (similar benefits minus the side effects). S23 compares to the steroids of Anavar and Winstrol.
S23 has more side effect risk than the average SARM, researchers can control them effectively with sensible use.
S23’s powerful benefits are only rivaled by a couple of other SARMs, including RAD 140 and Andarine, with LGD-4033 being another compound with the potential for similar fat loss and muscle-gaining benefits as S23.
Typically, S23 researchers stack S23 with at least one of these other SARM.
BENEFITS:
23S has wide-ranging benefits. Potential benefits and effects that you can expect when using S23 SARM:
Building lean mass is a prime benefit of S23 and why many researchers use it.
Despite its steroid-like effects, S23 does not typically cause water retention, so gains will be clean and bloat-free.
Some strength gains can also be expected, but the most significant benefit in this area is maintaining your strength when on a cutting cycle, where a calorie deficit can start to zap strength and stamina, resulting in weaker workouts and a reduction in muscle.
S23 helps sustain your strength to continue training at a higher intensity.
Many S23 researchers have noted increased endurance, stamina, speed, and overall performance when using S23.
RISKS:
Compared with anabolic steroids, SARMs are generally considered safer, and this is also the case with S23. But as far as SARMs go, this is one of the more side effect-prone compounds, which can potentially bring about some effects that are similar to those seen with steroid use:
The higher your dosage of S23, the higher the risk of these side effects, and the more severe they could be.
During an S23 cycle, lower the dosage as necessary for the rest of the cycle if experiencing severe side effects.
DOSAGE:
Researchers should try to find the best dosage to get a balance of excellent results with minimal side effects.
S-23 will often be used at 10-30 mg/day for 4-8 weeks.
S23 has a short half-life of 12 hours, so splitting the dose during the day (morning and evening) helps to ensure it is always active in the body.
YK-11 is as close to an anabolic steroid as you can get. It works as a SARM and a myostatin inhibitor. By actively inhibiting myostatin, which inhibits muscle growth, the potential for building muscle is increased.
Myostatin prevents the muscle from growing, so by inhibiting it, you increase the potential for muscle growth when combined with resistance training. YK-11 decreases myostatin through the process of increasing the protein follistatin.
It’s common to see impressive muscle gains of up to 15 lbs after the first YK-11 cycle. It’s been found that some professional bodybuilders have a genetic inclination to be naturally myostatin deficient, indicating just how powerful YK-11 can be in promoting muscle growth.
BENEFITS:
Lean muscle gains and muscle preservation are the two significant benefits of YK-11, making it a versatile SARM. Regarding bulking, YK-11 can deliver some of the biggest possible gains from any SARM. This is primarily thanks to the unique myostatin inhibition properties you don’t get with other SARMs.
Bonus benefits include increased bone strength, which you’ll need for that extra muscle, and enhanced strength, so you’ll see a remarkable ability to lift heavier and heavier weights as the cycle progresses.
RISKS:
YK-11 brings about much more androgenic effects than other SARMs because it is a steroidal SARM, so you will be dealing with the familiar steroid-like androgenic side effects like hair loss and acne if you’re prone to these things:
YK-11 is potentially toxic to the liver. The side-effects experienced greatly depends on personal reaction and dosage.
DOSAGE:
YK-11 will often be used at 5-15 mg/day for 4-8 weeks.
YK-11 has a relatively short half-life of 6-8 hours. Many researchers prefer splitting the dosage between the day (morning, noon, and night) to ensure it’s always active in the body.
First time researchers using YK-11 should begin with a low dose of 5mg per day. After a week or two, it can be increased to 10mg daily.
15mg is still considered a moderate dose and is unlikely to cause severe side effects. This will vary from researcher to researcher.
The cycle length should be 8-12 weeks maximum.
PCT will be required.
ACP-105 is a potent Selective Androgen Receptor Modulator (SARM) with enhanced affinity for skeletal muscles, initially developed for degenerative disorders but increasingly used in sports and fitness.
ACP-105 selectively binds to androgen receptors, reducing high-density lipoproteins, increasing lean muscle mass, and avoiding estrogen level spikes.
BENEFITS:
ACP-105 undoubtedly results in various benefits; all directed towards making our body stronger with negligible side effects.
RISKS:
While ACP-105 is generally well-tolerated, it’s important to be aware of potential side effects, particularly at higher doses. Some individuals may experience:
ACP-105 is non-aromatizing, meaning it does not convert to estrogen and avoids estrogenic side effects.
ACP-105 has not been shown to cause liver or prostate damage.
DOSAGE & CYCLE:
When it comes to using ACP-105, proper dosage and cycling protocols are essential for maximizing benefits while minimizing risks.
The recommended dosage of ACP-105 is 1mg/kg body weight per day.
For men, this typically translates to 10-20mg per day, while women may opt for a lower dosage of 5-10mg per day.
Cycle length is another important consideration.
A typical ACP-105 cycle lasts 8-14 weeks, allowing sufficient time for the compound to exert its effects while avoiding potential long-term risks.
It’s crucial to incorporate post-cycle therapy (PCT) after an ACP-105 cycle to prevent testosterone suppression and maintain hormonal balance.
SR-9009 is a Rev-ErbA agonist.
The muscles, fat cells, and liver all contain the Rev-Erb protein, which SR-9009 can bind to. This boosts protein synthesis and enhances your anabolic state despite being able to do so without being a hormonal compound.
SR9009 is valued for promoting fat loss, mainly through its positive effects on metabolism. This compound was researched for its potential as an obesity treatment, which gives us a good idea of what it’s been created to do.
BENEFITS:
Endurance and stamina are the main effects of SR9009. This makes it attractive to endurance athletes like runners, swimmers, cyclists, and anyone doing cardio work.
Potential SR9009 benefits include:
Through a complex set of processes in the body, mitochondrial cells may be enhanced by SR-9009, particularly in fat cells, the liver, and skeletal muscle.
This action can help with the process of fat being used as an energy source, which can only result in you burning up more fat faster without losing muscle tissue.
RISKS:
To date, no human studies on the use of SR9009 have been published. SR9009 is generally considered safe for use in preclinical studies. However, it may be associated with some side effects including:
SR-9009 is still a little-known compound that shows many signs that it has excellent potential to be a relatively safe but highly effective product to use for cutting purposes in place of dangerous steroids. SR9009 should be used cautiously due to the lack of research and data.
SR9009 does not cause testosterone suppression, nor does it cause androgenic effects like balding or acne.
SR9009 has no hormonal activity and doesn’t impact testosterone or estrogen. A PCT is not required post cycle.
DOSAGE AND CYCLE:
There is no consensus on dosage for SR9009, and most researchers will experiment with their dosages and cycles.
Researchers recommend 20-30 mg/day for no longer than eight weeks. SR9009 has a short half-life of 4 hours. Splitting the dose during the day (morning, noon, late afternoon, and night) helps ensure it is always active in the body.
SR9011 is another compound that falls into the category of Rev-ErbA agonists, just like SR9009. It is sometimes referred to as a "cousin" of SR9009, as it shares similar properties and mechanisms of action.
Like SR9009, SR9011 is a research chemical that is being studied for its potential benefits in various areas, including metabolism, endurance, circadian rhythm regulation, and muscle growth.
SR9011 works by binding to the Rev-ErbA proteins in the body and influencing their activity levels. These proteins are involved in regulating various metabolic processes, including energy expenditure and lipid metabolism. By modulating the activity of Rev-ErbA proteins, SR9011 helps to enhance the metabolism and improve overall endurance.
Due to its influence on metabolism and endurance, SR9011 has potential applications in various areas. It may be beneficial for individuals looking to improve their athletic performance, as it could enhance endurance levels. Additionally, SR9011 might have implications in muscle growth, as it may contribute to the regulation of genes involved in muscle development.
Overall, SR9011 is a research chemical that shows promise in various areas related to metabolism, endurance, circadian rhythm, and muscle growth. Further research is needed to fully understand its effects and potential applications in these areas.
BENEFITS:
Potential SR90011 benefits include:
Muscle Mass Gains
SR9011 is believed to enhance muscle growth by increasing the expression of genes involved in muscle protein synthesis.
Improved Metabolic Rate
SR9011 has thermogenic effects, stimulating the metabolism and promoting fat burning. This helps individuals achieve a leaner physique and reduce body fat.
Improved Sleep Quality
Some studies suggest that SR9011 regulates the sleep-wake cycle, leading to better quality sleep. This contributes to improved recovery, hormone regulation, and overall well-being.
Anti-inflammatory
SR9011 has shown potential anti-inflammatory effects in animal studies. This is beneficial for individuals dealing with inflammation-related conditions, such as joint pain or autoimmune disorders.
Non-Hormonal
SR9011 is non-hormonal and doesn’t impact testosterone’s natural production. Researching use does not require a post cycle therapy (PCT).
DOSAGE & CYCLE:
As there is a lack of studies for the proper SR9011 dosage for human intake, the anecdotal claims of the majority of SR9011 researchers recommend an intake of 20 mg per day.
New researchers are advised to begin with a 10 mg dosage and increase once they are comfortable with it. Researchers should not exceed 30 mg per day.
Research use of SR9011 should not exceed two months because benefits will deteriorate.
Summary
SR9011 results are an effective increase in one’s energy processes and proper implementation of its role as a Rev-erb agonist. It makes its user achieve a higher metabolism rate and mitochondria.
Intake of SR9011 results in increased muscle mass, endurance, and recovery time. It lowers body fat and bad cholesterol. It is anti-inflammatory and decreases anxiety.
MK-677 (Ibutamoren) is a growth hormone secretagogue. It can mimic the functions of ghrelin, which boosts IGF-1 and growth hormone levels. This raises your ability to grow muscle and lose fat simultaneously. Research shows that MK-677 increases the natural secretion of growth hormone (GH) and insulin-like growth factor 1 (IGF-1) but does not affect cortisol levels.
MK-677 is one of the more unique compounds with the exciting benefit of potentially having some anti-aging effects. This comes alongside a wide range of desirable benefits to everyone, from bodybuilders to sporting athletes.
Moderate muscle gains of up to 10 lbs. are not uncommon. Potential fat loss effects are likely, but they are not as powerful as with some other compounds.
BENEFITS:
Quick muscle gains and fast reduction in body fat are the core benefits of Ibutamoren. Increasing bone mineral density and bone strength are additional benefits:
Appetite will more than likely increase with MK-677, which is good for bulking. A more unexpected benefit is a possible improvement in sleep quality, which can only help with your recovery process.
RISKS:
MK-677 may cause some serious side effects, especially at higher doses, which is to be expected when discussing a compound that raises growth hormone levels. Muscle and joint pain may occur and, in some cases, even swelling.
The dosage should be carefully planned to minimize these risks. Ibutamoren is mostly an unresearched compound, so many of its potential risks are still largely unknown.
DOSAGE & CYCLE:
Ibutamoren will often be used at 10-30 mg/day for about 8-16 weeks.
With the compound having a convenient half-life of 24 hours, it is typically taken daily and usually in the AM.
MK-677 works great at lower doses, so there is no need or benefit in jumping straight to a high dose with this compound.
Cardarine is a PPAR (Peroxisome Proliferator Activated Receptor) agonist. It’s trendy because of its excellent fat-burning activity, which makes it a popular cutting cycle compound.
Cardarine works effectively at promoting fat loss thanks to its ability to alter positively:
Quite extreme fat loss has been reported from Cardarine cycles; sometimes, up to 40 lbs. within three months. Often, Cardarine is used alongside SARMs like Ostarine.
Cardarine is a desirable compound for its powerful effects on athletes of just about any type, without steroid-type side effects.
However, there are important reasons why many people choose not to use Cardarine at all despite its incredible effects.
BENEFITS:
Cardarine focuses on receptors that are in muscles and fatty acids. These receptors can increase fatty acid oxidation capacity, which is the process of breaking down fatty acids. This makes Cardarine attractive, particularly for fat loss uses. Expect:
Cardarine is also useful for fat burning as it was also developed to help treat obesity. Cardarine can potentially act to burn fat for energy by changing the metabolism to increase the uptake of glucose in skeletal muscle tissue and to stimulate fatty acid oxidation.
Cardarine is known to reduce catabolism or loss of muscle when losing fat. Cardarine is often referred to as primarily a fat-loss compound.
RISKS:
Very few studies have been done with humans using Cardarine, and most of those have been small doses and short studies, so much remains unknown. In these studies, no serious Cardarine adverse effects were reported. There is often talk about the potential for Cardarine to cause cancer, but this has been far from proven scientifically:
Mild side effects of Cardarine:
Cardarine is not a stimulant, which gives it an edge over some other substances that stimulate the nervous system, causing many adverse effects.
DOSAGE:
Cardarine is often used at 10-20 mg/day for about 8-10 weeks. With the compound having a half-life of 16-24 hours, researchers can take it once daily (usually in the morning) to ensure it’s always active in your body.
Although trials on humans were run for 12 weeks, most researchers using Cardarine will normally stick to an 8-week cycle at a dose of between 10mg and 15mg daily.
Maximum dosage should not exceed 20mg for more advanced users.
The standard dosage range is from 10mg at the low end to 20mg daily. It is not recommended to exceed 20mg of Cardarine daily, which is more than enough to provide significant benefits, particularly regarding endurance.
GW0742, which is supposedly a better version of GW50156 (Cardarine). GW0742 works just like any PPAR delta agonist out there. It basically has two jobs: Turning fat into an energy source and increasing the oxidative capacity of our muscles.
Potential GW0742 Benefits:
Fat Burning
It acts as a PPAR delta agonist, enhancing fat metabolism and improving training energy and endurance.
Muscle Building
GW0742 helps in building lean muscle mass and improving bone density.
Cardiac Benefits
It has been shown to alleviate cardiac hypertrophy and reduce intestinal inflammation.
Lowers Total Cholesterol
A study performed on rats has shown that GW0742 has the ability to reverse cholesterol transport.
That cholesterol eventually ends up in our gastrointestinal tract and gets expelled when we go do our big business.
Reduces Inflammation in The Gut
There are many people out there suffering from inflammation in the gut and some help would surely be lifesaving. Research confirms that GW0742 successfully contributes to the decrease in inflammation in the gut.
Improves Lipid Profile
As with Cardarine, GW0742 has shown that even when administered in small dosages, it successfully enhances lipid metabolism in the heart.
This means that your lipid profile will look a lot better while taking GW0742, as it will handle triglycerides much easier from now on.
Associated Side Effects of GW0742
GW0742 side effects are very uncommon. There have been some side effects associated with the use of this drug wherein the researcher had one of the issues listed below at some point while being on GW0742. However, these side effects weren’t confirmed to be associated with the treatment and could have been a coincidence and not related to the use of GW0742. Despite this, it was listed as a side effect associated with GW0742 even though these associated side effects are very uncommon.
Side effects associated with GW0742 may include the following:
GW0742 Dosage
The ideal dosage of GW0742 is unclear at this stage.
The majority of users follow a Cardarine dosage protocol. That would have you taking 10 mg per day as a beginner user and stepping it up to 25 mg per day as an advanced user.
It is not recommended to exceed 25 mg per day.
Please reach us at revitalizehealthresearch@gmail.com if you cannot find an answer to your question.
SARMs selectively target muscle and bone tissue, potentially reducing the risk of side effects associated with steroids.
Yes, but starting with lower doses and understanding how they work before incorporating them into your routine is important.
Consider your goals (muscle building, fat loss, etc.) and research which SARM aligns with those objectives.
While considered safer than steroids, it’s important to follow recommended dosages and consult with a healthcare professional.
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